منابع مشابه
Metformin targets multiple signaling pathways in cancer
Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 diabetes, has become the focus of intense research as a candidate anticancer agent. Here, we discuss the potential of metformin in cancer therapeutics, particularly its functions in multiple signaling pathways, including AMP-activated protein kinase, mammalian target of rapamycin, insulin...
متن کاملMetformin differentially activates ER stress signaling pathways without inducing apoptosis
Endoplasmic reticulum stress signaling (ERSS) plays an important role in the pathogenesis of diabetes and heart disease. The latter is a common comorbidity of diabetes and worsens patient outcome. Results from clinical studies suggest beneficial effects of metformin - a widely used oral drug for the treatment of type 2 diabetes - on the heart of diabetic patients with heart failure. We therefor...
متن کاملMetformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.
A number of factors have been identified that increase the risk of hepatocellular carcinoma (HCC). Recently it has become appreciated that type II diabetes increases the risk of developing HCC. This represents a patient population that can be identified and targeted for cancer prevention. The biguanide metformin is a first-line therapy for the treatment of type II diabetes in which it exerts it...
متن کاملMolecular Pathways Molecular Pathways: Preclinical Models and Clinical Trials with Metformin in Breast Cancer
Metformin, an oral biguanide widely used to treat diabetes, has considerable potential and is in clinical trials as an experimental preventive or therapeutic agent for a range of cancers. Direct actions targeting cellular pathways, particularly via AMP-activated protein kinase and through inhibiting mitochondrial ATP synthesis, or systemic mechanisms involving insulin and insulin-like growth fa...
متن کاملMetformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways
BACKGROUND Metformin is the first line of oral antidiabetic drug in the biguanide class for treatment of type 2 diabetes. Increasing evidence has suggested that it is a potential anti-tumor drug. However, the mechanisms underlying inhibiting tumor development remain elusive, especially in bladder tumors. METHODS T24 and J82 cell lines were used as an in vitro model, and 24 female SD rats were...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2012
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e3283559b22